Endocrine Abstracts

Neuroendocrine tumors (NETs) of GI tract are a heterogeneous group of neoplasms that secrete peptides and amines. Small bowel NETs originate from enterochromaffin (EC) cells and secrete chromogranin A (CgA) and serotonin (5-HT). NETs are highly vascular, a reflection of increased tumour related angiogenesis. Adenosine, the major regulator of angiogenesis, is released by enhanced degradation of ATP, during cellular stress, damage and hypoxia.Aims: Aims of...

Aim: To analyse outcome of transsphenoidal surgery for acromegaly in Wales using stringent remission criteria.Method: We retrospectively analysed 90 patients who underwent transsphenoidal surgery (performed by 3 surgeons) as initial therapy for acromegaly in our centre between January 1980 and December 2001. A combination of modern, evidence-based remission criteria including mean day curve GH < 5 mU/l and /or a nadir GH < 2 mU/l after an oral glucose tolerance test ...